Glyphosate is a broad-spectrum systemic herbicide (known to the world under its trade name Roundup®). Among its many nefarious health effects, glyphosate disrupts the way the body manages sulfur.In the process of examining all the known toxic chemicals in the environment and assessing which one(s) would be most likely to be causal for autism—given the specific comorbidities associated with autism
Both glyphosate and autism are associated with low melatonin, impaired sulfur metabolism (and low serum sulfate), low vitamin D, sleep disorders, disrupted gut bacteria, and more. Glyphosate—already a very dangerous chemical on its own—causes aluminum to be much more toxic. Glyphosate and aluminum can be viewed as "partners in crime," working synergistically with one another
Health Probelms
- First, glyphosate preferentially kills beneficial bacteria in the gut, which allows pathogens such as C. difficile to overgrow. Not only does this lead to leaky gut syndrome, but C. difficile produces something called p-Cresol, a phenolic compound that is toxic to other microbes via its ability to interfere with metabolism. (C. difficile is one of only a few bacteria able to ferment tyrosine into p-Cresol.) As it happens, p-Cresol also promotes aluminum uptake by cells. P-Cresol is a known biomarker for autism and is also an important factor in kidney failure,which leads to aluminum retention in tissues and eventually to dementia.
- Glyphosate also serves to increase aluminum toxicity by "caging" aluminum to promote its entry into the body. Glyphosate promotes calcium uptakeby voltage-activated channels, which allow aluminum to gain entry as a calcium mimetic. Aluminum then promotes calcium loss from bones, contributing to pineal gland calcification.
- Bringing melatonin back into the discussion, glyphosate interferes with what is known as the shikimate pathway. Although humans do not have the shikimate pathway, our gut flora do, and we depend on our gut flora to supply us with essential amino acids and many other things. Disruption of the shikimate pathway in our gut results in depletion of tryptophan, which is the sole precursor to melatonin. Besides needing melatonin to transport sulfate into the brain, we also need melatonin to reduce heavy metal toxicity. Where supplies of melatonin are adequate, melatonin will bind to aluminum, cadmium, copper, iron, and lead, and reduce their toxicity. Where melatonin is low, a lot of damage can result.
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